Monday, November 12, 2012

What is the Role of Insulin in Human Body?

Thiazolidinediones which ar new antidiabetic drug drugs, possess anti-inflammatory effects in vitro (Ebeling and associates, 1999). The drugs increase off-base insulin sensitivity and are effective as both monotherapy and confederacy therapy (Brown & Brillon, 1999). Troglitazone is a useful antihyperglycemic agent, but in about 1.9 part of patients hepatotoxicity has occurred, which may be severe and even fatal. Frequent supervise of serum liver chemistries in patients taking the drug is essential. (Kohlroser, Mathai, Reichheld, touchstone & Bonkovsky, 2000).

* Inhaled Insulin - A new method of delivering insulin, namely inhaled insulin operates to provide an utility(a) to painful injections (Leslie, 1999). Empirical research suggests that, once plasma glucose levels are normalized, postprandial glucose levels can be maintained below diabetic levels by delivering 1.5 U/kg insulin into the lungs 5 min ahead the ingestion of a meal. (Laube, Benedict & Dobs, 1998). Advantages are said to be site-directed delivery, improved compliance with treatment regimen, and improved self-administration (Gonda, Schuster, Rubsamen, Lloyd, Cipolla & Farr, 1998).

* Insulin draw ups and pen needles - Pens and pen needles have been proven to be simple to use and readily accepted by patients as well as providing patients with significantly superior metabolic control (Piniek, Kurth & Bartels, 1991). Regarding safety concerns, studies of needles


Gonda, I., Schuster, J.A., Rubsamen, R.M., Lloyd, P., Cipolla, D. & Farr, S.J. (1998).
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Inhalation delivery systems with compliance and disease watchfulness capabilities. Journal of Controlled Release, 53(1-3), 269-274.

Agrawal, P., Rai, V. & Singh, R.B. (1996). Randomized placebo-controlled, single blind trial of saintly basil leaves in patients with noninsulin-dependent diabetes mellitus. International Journal of Clinical pharmacological Therapy, 34(9), 406-409.

Rai, V. (1997). Effect of Ocimum sanctum leaf powder on blood lipoproteins, glycated proteins, and total amino acids in patients with non-insulin-dependent diabetes mellitus. Journal of commissariat and Environmental Medicine, 7, p. 113.

Foster, S.A., Good, J.V., Small, R.E. (1999). Home blood glucose monitoring. Annuals of Pharmacotherapy, 33(3), 355-363.

Piniek, W., Kurth, E. & Bartels, O. (1991). [Insulin injection aid. Experiences with its use in Type II diabetes patients]. Fortscher Medicine, 109(31), 627-630.


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